Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir결합된 컴퓨터 및 세포 스크리닝은 렌바티닙과 렘데시비르에 의한 SARS-CoV-2의 상승적 억제를 확인합니다Animal Published on 2021-07-282022-09-10 Journal: The Journal of General Virology [Category] SARS, 신약개발, 치료제, [키워드] anti-cancer treatment Antiviral compounds antiviral drug approved cellular Combined Compound COVID-19 diclazuril disease severity docking drug drug synergy DrugBank enzyme exhibited functional Future Host host receptor Human identify in vitro independent independent of inhibit inhibit SARS-CoV-2 inhibited Inhibition assays inhibitor lenvatinib management mechanism nucleoside Pazopanib performed protease Protease inhibitor Rapid Remdesivir Replication SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication subsequent sunitinib synergistic synergistic effect synergy target the SARS-CoV-2 therapeutic option tyrosine Vero-CCL81 Vero-CCL81 cells Viral viral replication [DOI] 10.1099/jgv.0.001625 PMC 바로가기 [Article Type] Animal
SARS-CoV-2 variants reveal features critical for replication in primary human cellsSARS-CoV-2 변이체는 1차 인간 세포에서 복제에 중요한 기능을 나타냅니다Research Article Published on 2021-03-242022-08-13 Journal: PLoS Biology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus BEpCs bronchial epithelial cell causative agent change characterization characterized circulation clade contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 pandemic Critical D614G variant deaths Deletion determine effort epithelial cells European exhibited experiments expressing feature furin furin cleavage site Genetic variant highlight human population human respiratory cell human SARS-CoV-2 Infection isolate kinetic MONITOR NSP2 ORF3a pandemic Patient Phenotypes primary differentiated human bronchial epithelial cells primary human cell primary human cells primary human respiratory cells Q57H Replication representing respiratory SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants selected sequence Sequencing sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike D614G variant Spread Substitution substitutions T85I the Spike Transmission variant variants of concern Vero-CCL81 Vero-CCL81 cell Vero-CCL81 cells Viral virus virus replication virus stocks while [DOI] 10.1371/journal.pbio.3001006 PMC 바로가기 [Article Type] Research Article